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In a further embodiment, the present invention is directed toward a modified TetR(Z) protein comprising an amino acid substitution at an amino acid position selected from the group consisting of positions 63, 74, 75, 95, 99, 100, 103, 104, 105, 107, 118, 137, 165, 166, 167, 181, 185, and 189 of the TetR(Z) protein as depicted in SEQ ID NO: 50, wherein said modified TetR(Z) protein binds a TetR(Z) operator sequence with greater affinity in the presence of tetracycline than in the absence of tetracycline, where: the amino acid substitution at position 63 is asparagine, the amino acid substitution at position 74 is valine; the amino acid substitution at position 75 is valine; the amino acid substitution at position 95 is glutamine; the amino acid substitution at position 99 is selected from the group consisting of glycine and glutamic acid; the amino acid substitution at position 99 is glycine; the amino acid substitution at p. Many studies have shown that tetracycline is an effective treatment option for acne? Se une intensamente a las proteínas plasmáticas por lo cual no pasa directamente en el filtrado, sino son secretados por el transportador de ácidos orgánicos para alcanzar su sitio de acción!

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